Journal article
Colorimetric histology using plasmonically active microscope slides
E Balaur, S O’ Toole, AJ Spurling, GB Mann, B Yeo, K Harvey, C Sadatnajafi, E Hanssen, J Orian, KA Nugent, BS Parker, B Abbey
Nature | NATURE PORTFOLIO | Published : 2021
Abstract
The human eye can distinguish as many as 10,000 different colours but is far less sensitive to variations in intensity1, meaning that colour is highly desirable when interpreting images. However, most biological samples are essentially transparent, and nearly invisible when viewed using a standard optical microscope2. It is therefore highly desirable to be able to produce coloured images without needing to add any stains or dyes, which can alter the sample properties. Here we demonstrate that colorimetric histology images can be generated using full-sized plasmonically active microscope slides. These slides translate subtle changes in the dielectric constant into striking colour contrast whe..
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Grants
Awarded by Victorian Cancer Agency
Funding Acknowledgements
B.A., E.B. and K.A.N. acknowledge the support of the Australian Research Council through the Centre of Excellence in Advanced Molecular Imaging (CE140100011). Fellowship funding from the Victorian Cancer Agency and grant funding from the National Breast Cancer Foundation NBCF (IIRS-21-069) is acknowledged by B.S.P. Funding from the National Breast Cancer Foundation (NBCF Prac. 16-006) and Sydney Breast Cancer Foundation is acknowledged by S.O'T. B.A. acknowledges support from the La Trobe Biomedical and Environmental Sensor Technology (BEST) Research Centre. The authors gratefully acknowledge X. Li from the La Trobe Statistics Consultancy Platform for help and advice with the statistical analysis of the data. This work was performed in part at the Melbourne Centre for Nanofabrication (MCN) in the Victorian Node of the Australian National Fabrication Facility (ANFF).